Description anemia Anemia is generally blood disease – particularly red blood cells (erythrocytes). This is a condition in which the reduced hemoglobin (Hb = red blood pigment which carries oxygen) below the specified ranges for the age and sex of the…
breakdown of red blood cells
Other names: hemolysis, RBC decay
Breakdown of red blood cells is technically called hemolysis, its clinical manifestation is then anemia(anemia) – A man is pale, tired, with declining physical performance, zadýchává and has accelerated heartbeat (pulse higher).
Anemia from red blood cell breakdown can have many causes from congenital disorders after acquired. Among the genetically inherited diseases include, for example, sickle cell anemia,thalassemia or spherocytosis. Generally speaking, it is always somehow disrupted the shape of blood cells, allowing more blood cell is then destroyed when passing through capillaries and spleen, blood cell or missing in one of the most important enzymes, and it is a disorder of hemoglobin – hemoglobin – and this is somehow altered.
Other times can be a red blood cell destruction caused by causes outside their cells – the damage antibodies, bacterial toxins or parasites, extensive burns, as well as liver cirrhosis, malaria,thrombotic thrombocytopenic purpura, Husum (hemolytic uremic syndrome), or DIC (disseminated intravascular coagulation).
Acute hemolytic reaction occurs when blood group incompatibility blood transfusion, which is a drop in pressure, rapid heartbeat, chest pain, fever and chills. Therefore, the blood of the donor and recipient blood carefully controlled. Acute and severe destruction of red blood cells also occurs when non-compliance of certain blood groups (not known ABO system, but the system Rh) between mother and fetus, which leads to damage.
Except congenital anemia rise to most slowly, because they are still some reserves organism and forms new blood cells. The disintegration of hemoglobin A yellow pigment, bilirubin. This coloration can be observed eg. To injury from falling (classically broken knee) when the bruise, which gradually changes color. When hemolysis from various causes can occur yellowing of the mucous membranes, sclera and excessive hemolysis and yellow skin. This condition is called jaundice (jaundice), when the blood is full of free bilirubin (ie not bound to blood proteins). Some people have to jaundice increased gradients yet that lack enzymatic activity in the liver and bilirubin, which is cleared by the liver, is held longer in the blood. Such is the case with Gilbert’s disease, which of course is not too serious and taxes contrary, individuals have another advantage – reduced propensity for atherosclerosis. However, there are several serious failures relating to the processing of bilirubin, are fortunately rare.
If you observe on your body yellowing (excluding ordinary bruises, but they try to make up can often be a sign of blood clotting defects and also deserve a visit to the doctor), sometimes orange, definitely go to the doctor. Likewise, if you are pale and increasingly tired than before.